Eribulin

Definition

An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.

Also known as 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one, E 7389, E-7389, ER 086526, ER-086526, ER086526, ERIBULIN — per NCIT

Also identified as

• ATC L01XX41 per RXNORM
• NCIT NCIT:C96748 per NCIT
• SCTID 708166000 per RXNORM
• SCTID 767582004 per RXNORM
• UNII LR24G6354G per RXNORM

Indications