Vandetanib

Definition

An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.

Also known as AZD 6474, AZD-6474, AZD6474, Caprelsa, Lucivand, VANDETANIB, Zactima, ZD-6474, ZD6474 — per NCIT

Also identified as

• ATC L01EX04 per RXNORM
• NCIT NCIT:C2737 per NCIT
• SCTID 418260004 per RXNORM
• SCTID 418520004 per RXNORM
• UNII YO460OQ37K per RXNORM