Cobicistat

Definition

A cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents. Upon administration, cobicistat inhibits the liver enzyme CYP3A4 and limits the breakdown of co-administered agents that are metabolized by CYP3A4, and increases the concentration, systemic exposure and efficacy of the co-administered agent.

Also known as 2,7,10,12-Tetraazatridecanoic Acid, 12-Methyl-13-(2-(1-methylethyl)-4-thiazolyl)-9-(2-(4-morpholinyl)ethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-Thiazolylmethyl Ester, (3R,6R,9S)-, COBICISTAT, GS 9350, Tybost — per NCIT

Also identified as

• ATC V03AX03 per RXNORM
• NCIT NCIT:C97360 per NCIT
• SCTID 710109003 per RXNORM
• SCTID 714771003 per RXNORM
• UNII LW2E03M5PG per RXNORM

Indications