Enzalutamide

Definition

An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.

Also known as ASP9785, Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-, ENZALUTAMIDE, MDV 3100, MDV-3100, MDV3100, Xtandi — per NCIT

Also identified as

• ATC L02BB04 per RXNORM
• NCIT NCIT:C71744 per NCIT
• SCTID 703125003 per RXNORM
• SCTID 703684000 per RXNORM
• UNII 93T0T9GKNU per RXNORM

Indications