Pasireotide

Definition

A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting a much higher binding affinity for somatostatin receptors 1, 3, and 5 than octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. This agent is more potent than somatostatin in inhibiting the release of human growth hormone (HGH), glucagon, and insulin.

Also known as Cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-), PASIREOTIDE, SOM230 — per NCIT

Also identified as

• ATC H01CB05 per RXNORM
• NCIT NCIT:C69131 per NCIT
• SCTID 704266003 per RXNORM
• SCTID 704267007 per RXNORM
• UNII 98H1T17066 per RXNORM

Indications