Crofelemer

Definition

An oligomeric proanthocyanidin extracted from the latex produced by the tree Croton lechleri (Euphorbiaceae), with antidiarrheal, and potential antiviral and antimicrobial activities. Upon oral administration, crofelemer acts locally within the gastrointestinal (GI) tract by inhibiting both the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion (Cl-) channel and the calcium-activated Cl- channel (CaCC) expressed on the luminal surface of enterocytes. This inhibits the secretion of chloride ions into the intestinal lumen and prevents high volume water loss. By normalizing Cl- and water balance in the intestines, crofelemer relieves secretory diarrhea.

Also known as CROFELEMER, Fulyzaq, SP 303, SP-303, Virend — per NCIT

Also identified as

• ATC A07XA06 per RXNORM
• NCIT NCIT:C125392 per NCIT
• SCTID 725534007 per RXNORM
• SCTID 763594007 per RXNORM
• UNII PY79D6C8RX per RXNORM

Indications