Pomalidomide
Pomalidomide
Definition
An orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.
Also known as 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide, 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione, 4-Aminothalidomide, Actimid, CC 4047, CC-4047, CC4047, Imnovid, POMALIDOMIDE, Pomalyst — per NCIT
Also identified as
- ATC L04AX06 per RXNORM
- NCIT NCIT:C72560 per NCIT
- SCTID 703789000 per RXNORM
- SCTID 703790009 per RXNORM
- UNII D2UX06XLB5 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Multiple myeloma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.