Vilanterol

Definition

A long-acting beta-2 adrenergic agonist, with bronchodilator activity. Upon administration, vilanterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells.

Also known as GW 642444, GW-642444, GW642444, VILANTEROL — per NCIT

Also identified as

• NCIT NCIT:C152875 per NCIT
• SCTID 702408004 per RXNORM
• SCTID 720194004 per RXNORM
• UNII 028LZY775B per RXNORM

Indications