Metreleptin

Definition

A recombinant human leptin analog composed of human leptin with the addition of a methionine residue at its amino terminus, that may be used for the treatment of leptin deficiency. Upon administration, metreleptin binds to and activates the human leptin receptor (ObR). This activates leptin/ObR-mediated signaling pathways. Leptin, a hormone predominantly secreted by adipose tissue, plays an important role in maintaining energy homeostasis.

Also known as METRELEPTIN, Myalept, N-Methionylleptin — per NCIT

Also identified as

• ATC A16AA07 per RXNORM
• NCIT NCIT:C170171 per NCIT
• SCTID 703361000 per RXNORM
• SCTID 715594006 per RXNORM
• UNII TL60C27RLH per RXNORM

Indications