Miltefosine

Definition

An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04)

Also known as 2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt, Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt, D-18506, Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate, Hexadecylphosphocholine, Miltefosin, Miltefosina, MILTEFOSINE, Miltefosinum, Miltex, n-Hexadecylphosphorylcholine — per NCIT

Also identified as

• ATC P01CX04 per RXNORM
• NCIT NCIT:C1170 per NCIT
• SCTID 713642004 per RXNORM
• SCTID 713676008 per RXNORM
• UNII 53EY29W7EC per RXNORM

Indications

Organ Effects

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.