Dalbavancin

Definition

A second-generation, semi-synthetic lipoglycopeptide antibiotic, with bactericidal activity against a variety of gram-positive bacteria. Upon administration, dalbavancin binds, at a site different from that of penicillins and cephalosporins, tightly to the D-alanyl-D-alanine portion of peptidoglycan chains, thereby preventing peptidoglycan elongation and interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins and induces cell wall lysis.

Also known as DALBAVANCIN, Dalvance, MDL 63,397, Ristomycin A Aglycone, 5,31-Dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-(2-deoxy-2-((10-methyl-1-oxoundecyl)amino)-beta-D-glucopyranuronosyl)-38-(((3-(dimethylamino)propyl)amino)carbonyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-, VER001 — per NCIT

Also identified as

• ATC J01XA04 per RXNORM
• NCIT NCIT:C116741 per NCIT
• SCTID 703917001 per RXNORM
• SCTID 703919003 per RXNORM
• UNII 808UI9MS5K per RXNORM

Indications