Efinaconazole

Definition

A triazole compound, with antifungal activity. Upon administration, efinaconazole targets, binds to and inhibits 14-alpha-demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis.

Also known as (2R,3R)-2-(2,4-difluorofenil)-3-(4-metilenopiperidin-1-il)-1-(1h-1,2,4-triazin-1-il)butan-2-ol, 1-Piperidineethanol, alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1- ylmethyl)-, (alphaR,betaR)-, Clenafin, EFINACONAZOLE, Jublia, KP 103, KP-103, KP103 — per NCIT

Also identified as

• ATC D01AC19 per RXNORM
• NCIT NCIT:C97998 per NCIT
• SCTID 703880007 per RXNORM
• SCTID 703881006 per RXNORM
• UNII J82SB7FXWB per RXNORM

Indications