Tavaborole

Definition

A boron-containing small molecule antifungal agent with broad-spectrum activity against filamentous fungi, including both mold and yeast. 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole inhibits fungal cytoplasmic leucyl-tRNA synthetase by preventing catalytic turnover, thus inhibiting synthesis of leucyl-tRNA(Leu) and consequentially blocking protein synthesis.

Also known as 5-Fluoro-1,3-Dihydro-1-Hydroxy-2,1-Benzoxaborole, AN2690, TAVABOROLE — per NCIT

Also identified as

• ATC D01AE24 per RXNORM
• NCIT NCIT:C81725 per NCIT
• SCTID 716264009 per RXNORM
• SCTID 763516005 per RXNORM
• UNII K124A4EUQ3 per RXNORM

Indications