Naloxegol

Definition

A pegylated form of naloxone, a peripherally-acting mu-opioid receptor antagonist, that can be used to reduce opioid-induced symptoms. Upon administration, naloxegol binds to and blocks mu-opioid receptors in the peripheral nervous system. This prevents peripheral opioid receptor activation and abrogates opioid-induced side effects, such as opioid-induced constipation (OIC). Pegylation of naloxone reduces permeability across the blood-brain barrier (BBB) and prevents this agent from interfering with the analgesic activity of opioid receptor agonists.

Also known as AZ13337019, Morphinan-3,14-diol, 4,5-Epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)- 17-(2-propenyl)-, (5alpha,6alpha)-, Movantik, NALOXEGOL, NKTR-118 — per NCIT

Also identified as

• ATC A06AH03 per RXNORM
• NCIT NCIT:C97506 per NCIT
• SCTID 719411008 per RXNORM
• SCTID 763564001 per RXNORM
• UNII 44T7335BKE per RXNORM

Indications