Olaparib

Definition

A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

Also known as AZD 2281, AZD-2281, AZD2281, KU 0059436, KU-0059436, KU0059436, Lynparza, Olanib, OLAPARIB, Olaparix, PARP Inhibitor AZD2281 — per NCIT

Also identified as

• ATC L01XK01 per RXNORM
• NCIT NCIT:C71721 per NCIT
• SCTID 432162002 per RXNORM
• SCTID 432885003 per RXNORM
• UNII WOH1JD9AR8 per RXNORM

Indications