Bezlotoxumab
ATC Code
J06BC03
Bezlotoxumab
Definition
A human monoclonal antibody directed against Clostridium difficile Toxin B (TcdB), with anti-toxin activity. Upon intravenous infusion, the two Fab regions of bezlotoxumab bind to two distinct epitopes within the N-terminal half of the TcdB combined repetitive oligopeptide (CROP) domain, blocking the carbohydrate binding pockets of the toxin and preventing binding of the toxin to target host cells. TcdB is one of two exotoxins responsible for the symptoms of Clostridium difficile infections.
Also known as BEZLOTOXUMAB, MK 6072, MK-6072, MK6072, Zinplava — per NCIT
Also identified as
- ATC J06BC03 per RXNORM
- NCIT NCIT:C153084 per NCIT
- SCTID 723524001 per RXNORM
- SCTID 763703008 per RXNORM
- UNII 4H5YMK1H2E per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Clostridium infectious disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Clostridium infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |