Telotristat Ethyl

Definition

The ethyl ester form of telotristat, a tryptophan hydroxylase (TPH) inhibitor, with potential anti-serotonergic activity. Upon administration, telotristat binds to and inhibits the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.

Also known as LX 1032, LX 1606, LX-1032, LX-1606, LX1032, LX1606, TELOTRISTAT ETHYL — per NCIT

Also identified as

• NCIT NCIT:C150126 per NCIT
• SCTID 733879005 per RXNORM
• UNII 8G388563M7 per RXNORM

Indications