Abaloparatide

Definition

A 34 amino acid synthetic analog of human parathyroid hormone-related protein (PTHrP) (PTHrP(1-34) analog), with bone-growing and bone density conserving activities. Upon subcutaneous administration, abaloparatide acts similar to PTHrP and targets, binds to and activates parathyroid hormone 1 (PTH1) receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in osteoblasts and bone stromal cells. PTH1R activates the cyclic AMP (cAMP) signaling pathway and the bone anabolic signaling pathway, leading to bone growth, increased bone mineral density (BMD) and volume. This correlates with increased bone mass and strength and prevents or treats osteoporosis and decreases fractures.

Also known as ABALOPARATIDE, BA058, BIM-44058, C2.29-methyl(22-L-glutamic Acid(F>E),23-L-leucine(F>L),25-L-glutamic Acid(H>E),26-L-lysine(H>K),28-L-leucine(I>L),30-L-lysine(E>K),31-L-leucine(I>L))Human Parathyroid Hormone-related Protein-(1-34)-proteinamide, Tymlos — per NCIT

Also identified as

• ATC H05AA04 per RXNORM
• NCIT NCIT:C158818 per NCIT
• SCTID 735229000 per RXNORM
• SCTID 763500008 per RXNORM
• UNII AVK0I6HY2U per RXNORM

Indications