Apalutamide

Definition

A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.

Also known as 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-N-methylbenzamide, APALUTAMIDE, ARN 509, ARN-509, ARN509, Erleada, JNJ 56021927, JNJ-56021927 — per NCIT

Also identified as

• ATC L02BB05 per RXNORM
• NCIT NCIT:C92574 per NCIT
• SCTID 766972001 per RXNORM
• SCTID 766973006 per RXNORM
• UNII 4T36H88UA7 per RXNORM

Indications