Talazoparib

Definition

An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

Also known as BMN 673, BMN-673, BMN673, TALAZOPARIB — per NCIT

Also identified as

• ATC L01XK04 per RXNORM
• NCIT NCIT:C95733 per NCIT
• SCTID 782199007 per RXNORM
• SCTID 782211002 per RXNORM
• UNII 9QHX048FRV per RXNORM

Indications