Emapalumab

ATC Code L04AG09

Emapalumab

Definition

A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration, emapalumab binds to and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses the activation of the immune system. IFNg, a cell-signaling protein, plays a key role in the regulation and activation of the immune system; its upregulation is associated with certain auto-immune and auto-inflammatory diseases in which the immune system is abnormally activated.

Also known as Anti-IFN gamma Monoclonal Antibody NI-0501, Anti-IFNg mAb NI-0501, Anti-interferon gamma Monoclonal Antibody NI-0501, EMAPALUMAB, Emapalumab-lzsg, Gamifant, NI 0501, NI-0501, NI0501 — per NCIT

Also identified as