Glasdegib
Glasdegib
Definition
An orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Glasdegib appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.
Also known as GLASDEGIB, PF 04449913, PF-04449913, PF04449913 — per NCIT
Also identified as
- ATC L01XJ03 per RXNORM
- NCIT NCIT:C84862 per NCIT
- SCTID 782978008 per RXNORM
- SCTID 783019002 per RXNORM
- UNII K673DMO5H9 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Acute myeloid leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.