Luspatercept

Definition

A soluble, recombinant fusion protein composed of a modified form of the extracellular domain of human activin receptor type IIb (ActRIIb) and linked to the human IgG1 Fc domain, with red blood cell stimulating activity. Upon subcutaneous administration, luspatercept inhibits several ligands in the transforming growth factor (TGF)-beta superfamily. This prevents activation of a variety of TGF-beta superfamily members involved in late stage erythropoiesis and results in an increased differentiation and proliferation of erythroid progenitors. luspatercept acts at a different, later stage than erythropoietin. This agent ultimately enhances red blood cell production and prevents anemia.

Also known as ACE 536, ACE-536, ACE536, LUSPATERCEPT, Luspatercept-aamt, Reblozyl — per NCIT

Also identified as

• ATC B03XA06 per RXNORM
• NCIT NCIT:C104012 per NCIT
• SCTID 830158005 per RXNORM
• SCTID 830211009 per RXNORM
• UNII AQK7UBA1LS per RXNORM

Indications