Bempedoic Acid

Definition

An orally bioavailable prodrug and inhibitor of adenosine triphosphate-citrate lyase (ACL), with anti-hyperlipidemic activity. Upon oral administration, bempedoic acid becomes activated to its thioester form with coenzyme A (CoA) by the enzyme very long-chain acyl-CoA synthetase 1 (ACSVL1; SLC27A2) in the liver. The activated form inhibits ACL, thereby preventing the liver's biosynthesis of cholesterol. This lowers low-density lipoprotein cholesterol (LDL-C) levels. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway.

NCIT:C166494 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as BEMPEDOIC ACID, Nexletol — per NCIT

Also identified as

ATC C10AX15 per RXNORM
NCIT NCIT:C166494 per NCIT
SCTID 870523005 per RXNORM
SCTID 870609002 per RXNORM
UNII 1EJ6Z6Q368 per RXNORM

Indications

Disease	Relation	Source
Atherosclerosis	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Artery	may treat a disease of this organ	DERIVED · CC BY 4.0
Cardiovascular system	may treat a disease of this organ	DERIVED · CC BY 4.0

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.