Selumetinib

Definition

An orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.

Also known as ARRY-142886, AZD 6244, AZD-6244, AZD6244, MEK Inhibitor AZD6244, SELUMETINIB — per NCIT

Also identified as

• ATC L01EE04 per RXNORM
• NCIT NCIT:C66939 per NCIT
• SCTID 870689004 per RXNORM
• SCTID 870753001 per RXNORM
• UNII 6UH91I579U per RXNORM

Indications