Tacrolimus

Definition

A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.

NCIT:C1311 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as FK 506, FK-506, FK506, Fujimycin, Hecoria, Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, Prograf, Protopic, Tacforius, TACROLIMUS — per NCIT

Also identified as

ATC D11AH per NCIT
ATC L04AD per NCIT
NCIT NCIT:C1311 per NCIT

Indications

Disease	Relation	Source
Graft versus host disease	may prevent	MEDRT · Public domain (U.S. Government work)
Atopic eczema	may treat	MEDRT · Public domain (U.S. Government work)
Graft versus host disease	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Skin of body	may treat a disease of this organ	DERIVED · CC BY 4.0

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.