Tucatinib

Definition

An orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. Tucatinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

Also known as ARRY 380, ARRY-380, ARRY380, Irbinitinib, N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine, ONT 380, ONT-380, ONT380, TUCATINIB, Tukysa — per NCIT

Also identified as

• ATC L01EH03 per RXNORM
• NCIT NCIT:C77896 per NCIT
• SCTID 871698009 per RXNORM
• SCTID 871715004 per RXNORM
• UNII 234248D0HH per RXNORM

Indications