Molnupiravir

Definition

An orally bioavailable prodrug of EIDD-1931, the synthetic ribonucleoside derivative N4-hydroxycytidine and ribonucleoside analog, with potential antiviral activity against a variety of RNA viruses. Upon oral administration, molnupiravir, being a prodrug, is metabolized into its active form EIDD-1931 and converted into its triphosphate (TP) form. The TP form of EIDD-1931 is incorporated into RNA and inhibits the action of viral RNA-dependent RNA polymerase. This results in the termination of RNA transcription and decreases viral RNA production, and viral RNA replication.

Also known as EIDD 2801, EIDD-2801, EIDD2801, Lagevrio, MK 4482, MK-4482, MK4482, MOLNUPIRAVIR, N4-Hydroxycytidine, 5'-Isopropyl Ester, SARS-CoV-2 antiviral agents: molnupiravir, Uridine, 4-Oxime, 5'-(2-Methylpropanoate) — per NCIT

Also identified as

• ATC J05AB18 per RXNORM
• NCIT NCIT:C172633 per NCIT
• SCTID 1201931008 per RXNORM
• SCTID 1201933006 per RXNORM
• UNII YA84KI1VEW per RXNORM

Indications