Elacestrant

Definition

An orally available, selective estrogen receptor degrader (SERD), with antineoplastic activity. Upon oral administration, elacestrant acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the proteosomal degradation of the receptor. This prevents ER-mediated signaling and inhibits proliferation of ER-expressing cancer cells.

Also known as (6R)-6-(2-(Ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen-2-ol, ELACESTRANT, ER-306323, RAD 1901, RAD-1901, RAD1901, SERD/SERM RAD1901 — per NCIT

Also identified as

• ATC L02BA04 per RXNORM
• NCIT NCIT:C120211 per NCIT
• SCTID 43186711000001103 per RXNORM
• UNII FM6A2627A8 per RXNORM

Indications