Efbemalenograstim alfa

Definition

A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Efbemalenograstim alfa binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy.

Also known as EFBEMALENOGRASTIM ALFA, F-627, F627, Recombinant Dimeric G-CSF Fusion Protein F627, Rh G-CSF Fc Fusion Protein F-627 — per NCIT

Also identified as

• ATC L03AA18 per RXNORM
• NCIT NCIT:C102854 per NCIT
• UNII 5UPW5HJW3O per RXNORM

Indications