Iptacopan

ATC Code L04AJ08

Iptacopan

Definition

An orally available, small-molecule inhibitor of complement factor B (FB) with potential immunomodulatory activity. Upon administration, iptacopan binds to FB and prevents the formation of the alternative pathway (AP) C3-convertase (C3bBb). This limits the cleavage of C3 to the active fragment C3b and may prevent C3b-mediated extravascular hemolysis in certain complement-driven disorders such as paroxysmal nocturnal hemoglobinuria (PNH).

Also known as Factor B Inhibitor LNP023, IPTACOPAN, LNP 023, LNP-023, LNP023 — per NCIT

Also identified as