Lifileucel

Definition

A preparation of autologous tumor infiltrating lymphocytes (TILs), with potential antineoplastic activity. TILs are isolated from a patient's tumor tissue, cultured in vitro with high-dose interleukin-2 (lL-2), further selected based on antigen specificity and tumor reactivity, and the selected TILs are subsequently expanded. Upon re-introduction of lifileucel into the patient, the TILs re-infiltrate the tumor, specifically recognize the tumor-associated antigens (TAAs), and initiate tumor cell lysis. IL-2 induces the proliferation and expansion of TILs in vitro.

Also known as Amtagvi, Autologous TIL LN-144, Autologous Tumor Infiltrating Lymphocytes LN-144, Contego, LIFILEUCEL, Lifileuecel, LN 144, LN-144, LN144 — per NCIT

Also identified as

• ATC L01XL11 per RXNORM
• NCIT NCIT:C120552 per NCIT
• UNII R0835E18NH per RXNORM

Indications