Sotatercept

Definition

A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity. Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA signaling, resulting in the stimulation of osteoblast activity and the inhibition of osteoclast activity and so normal bone formation and increased bone mineral density and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN, preventing its lysosomal degradation and so extending its half-life in the circulatory system.

Also known as ACE-011, Decoy Activin Receptor ACE-011, SOTATERCEPT — per NCIT

Also identified as

• ATC C02KX06 per RXNORM
• NCIT NCIT:C80038 per NCIT
• SCTID 933398421000036106 per RXNORM
• UNII 0QI90BTJ37 per RXNORM

Indications