Acoramidis

Definition

A potent, highly selective, orally bioavailable transthyretin (TTR) stabilizer with potential disease-modifying activity. Upon oral administration, acoramidis binds to and stabilizes transthyretin (TTR), thereby preventing tetramer dissociation into monomers. This prevents misfolding of the TTR protein and inhibits the formation of TTR amyloid fibrils and the subsequent deposition of these insoluble protein clusters in the heart and peripheral nerves. TTR is a transport protein for thyroxine and retinol and is secreted by the liver into the blood. The accumulation of TTR amyloid fibrils may result in thickening and stiffening of the ventricular wall, leading to heart failure.

NCIT:C170791 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as ACORAMIDIS, AG 10, AG-10, AG10, ALXN 2060, ALXN-2060, ALXN2060, Transthyretin Stabilizer AG10, TTR Stabilizer AG10 — per NCIT

Also identified as

ATC C01EB25 per RXNORM
NCIT NCIT:C170791 per NCIT
UNII T12B44A1OE per RXNORM

Indications

Disease	Relation	Source
Cardiomyopathy	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Cardiovascular system	may treat a disease of this organ	DERIVED · CC BY 4.0
Heart	may treat a disease of this organ	DERIVED · CC BY 4.0
Musculature	may treat a disease of this organ	DERIVED · CC BY 4.0
Musculoskeletal system	may treat a disease of this organ	DERIVED · CC BY 4.0
Myocardium	may treat a disease of this organ	DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.