Tamoxifen
Tamoxifen
Definition
An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.
Also known as 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene, TAMOXIFEN, TMX — per NCIT
Also identified as
- ATC L02BA per NCIT
- NCIT NCIT:C62078 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast ductal adenocarcinoma | may prevent | MEDRT · Public domain (U.S. Government work) |
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Gynecomastia disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Pancreatic neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Precocious puberty | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Breast | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.