Rilzabrutinib

Rilzabrutinib

Definition

An orally bioavailable reversible covalent inhibitor of Bruton's tyrosine kinase (BTK), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, rilzabrutinib inhibits the activity of BTK. This prevents the activation of the B-cell antigen receptor (BCR) signaling pathway, and the resulting immune activation and inflammation. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival. In addition to B-cells, BTK is also expressed in other cells of hematopoietic origin, including monocytes, macrophages, neutrophils, mast cells, eosinophils and platelets, and plays an important role in both adaptive and innate immune responses.

Also known as PRN 1008, PRN-1008, PRN1008, RILZABRUTINIB — per NCIT

Also identified as