Paltusotine

Definition

An orally bioavailable, nonpeptide somatostatin receptor type 2 (SST2; SSTR2) agonist, with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities. Upon oral administration, paltusotine targets, binds to and activates SSTR2, which leads to an inhibition in the secretion of human growth hormone (hGH) in the pituitary gland and results in decreased production of insulin-like growth factor (IGF-1). This may inhibit IGF-1-mediated cell signaling pathways, and lead to apoptosis. SSTR2 is overexpressed by some neuroendocrine tumor cells, and GH is over-produced in the pituitary gland in acromegaly.

Also known as CRN 00808, CRN-00808, CRN00808, PALTUSOTINE — per NCIT

Also identified as

• ATC H01CB06 per RXNORM
• NCIT NCIT:C175836 per NCIT
• UNII F2IBD1GMD3 per RXNORM

Indications