Leuprolide

ATC Code L02AE02

Leuprolide

Definition

A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.

Also known as 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig), 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig), LEUPROLIDE, Leuprorelin — per NCIT

Also identified as

Indications

Disease Relation Source
Benign prostatic hyperplasia may treat MEDRT · Public domain (U.S. Government work)
Breast neoplasm may treat MEDRT · Public domain (U.S. Government work)
Endometriosis may treat MEDRT · Public domain (U.S. Government work)
Endometrium neoplasm may treat MEDRT · Public domain (U.S. Government work)
Infertility disorder may treat MEDRT · Public domain (U.S. Government work)
Leiomyoma may treat MEDRT · Public domain (U.S. Government work)
Ovarian cancer may treat MEDRT · Public domain (U.S. Government work)
Precocious puberty may treat MEDRT · Public domain (U.S. Government work)
Prostate cancer may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Female reproductive system may treat a disease of this organ DERIVED · CC BY 4.0
Genitourinary system may treat a disease of this organ DERIVED · CC BY 4.0
Male reproductive system may treat a disease of this organ DERIVED · CC BY 4.0
Prostate may treat a disease of this organ DERIVED · CC BY 4.0
Reproductive system may treat a disease of this organ DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.