Goserelin

Definition

A synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH) with antineoplastic activity. Goserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in a depot formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function. (NCI04)

NCIT:C1374 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 6-[O-(1,1-Dimethylethyl)-D-serine]-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) 2-(aminocarbonyl)hydrazide, GOSERELIN, ICI-118630 — per NCIT

Also identified as

ATC L02AE per NCIT
NCIT NCIT:C1374 per NCIT

Indications

Disease	Relation	Source
Breast neoplasm	may treat	MEDRT · Public domain (U.S. Government work)
Endometriosis	may treat	MEDRT · Public domain (U.S. Government work)
Prostate cancer	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Female reproductive system	may treat a disease of this organ	DERIVED · CC BY 4.0
Genitourinary system	may treat a disease of this organ	DERIVED · CC BY 4.0
Reproductive system	may treat a disease of this organ	DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.