Amlodipine
Amlodipine
Definition
A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.
Also known as AMLODIPINE — per NCIT
Also identified as
- ATC C08CA per NCIT
- ATC C09BB per NCIT
- ATC C09DB per NCIT
- ATC C09DX per NCIT
- ATC C09XA per NCIT
- ATC C10BX per NCIT
- NCIT NCIT:C61635 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Coronary artery disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypertensive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Prinzmetal angina | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.