Thalidomide
Thalidomide
Definition
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis.
Also known as .alpha.-Phthalimidoglutarimide, (-)-Thalidomide, (+)-Thalidomide, 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, 2, 6-Dioxo-3-phthalimidopiperidine, 2,6-Dioxo-3-phthalimidopiperidine, 3-Phthalimidoglutarimide, Alpha-Phthalimidoglutarimide, Contergan, Distaval, Kevadon, N-(2,6-Dioxo-3-piperidyl)phthalimide, N-Phthaloylglutamimide, N-Phthalylglutamic Acid Imide, Neurosedyn, Pantosediv, Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-, Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (+)-, Sedalis, Sedoval K-17, Sedoval K17, Softenon, Synovir, Talimol, THALIDOMIDE, Thalomid — per NCIT
Also identified as
- ATC L04AX per NCIT
- NCIT NCIT:C870 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Graft versus host disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Behçet's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Canker sore | may treat | MEDRT · Public domain (U.S. Government work) |
| Crohn's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Discoid lupus erythematosus | may treat | MEDRT · Public domain (U.S. Government work) |
| Erythema multiforme | may treat | MEDRT · Public domain (U.S. Government work) |
| Graft versus host disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Leprosy | may treat | MEDRT · Public domain (U.S. Government work) |
| Multiple myeloma | may treat | MEDRT · Public domain (U.S. Government work) |
| Renal cell carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.