Diphenhydramine
Diphenhydramine
Definition
A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.
Also known as 2-(Diphenylmethoxy)-N,N-dimethylethylamine, DIPHENHYDRAMINE, FAR 90X2, O-Benzhydryldimethylaminoethanol, PM 255, Probedryl, Rigidyl, S51, Syntedril — per NCIT
Also identified as
- ATC D04AA per NCIT
- ATC M01AE per NCIT
- ATC R06AA per NCIT
- NCIT NCIT:C61728 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Insomnia | may treat | MEDRT · Public domain (U.S. Government work) |
| Motion sickness | may treat | MEDRT · Public domain (U.S. Government work) |
| Perennial allergic rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Urticaria | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.