Valproic acid
Valproic acid
Definition
A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)
Also known as 2-Propylpentanoic Acid, 2-Propylvaleric Acid, Depakene, Di-n-propylacetic Acid, Stavzor, Valproate, VALPROIC ACID — per NCIT
Also identified as
- ATC N03AG per NCIT
- NCIT NCIT:C29536 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Migraine | may prevent | MEDRT · Public domain (U.S. Government work) |
| Alzheimer's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Bipolar disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Complex partial epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
| Epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.