Topiramate
Topiramate
Definition
A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.
Also known as beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate, Topamax, TOPIRAMATE — per NCIT
Also identified as
- ATC A08AA per NCIT
- ATC N03AX per NCIT
- NCIT NCIT:C47764 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Migraine | may prevent | MEDRT · Public domain (U.S. Government work) |
| Bipolar disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Epilepsy with generalized tonic-clonic seizures | may treat | MEDRT · Public domain (U.S. Government work) |
| Focal epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
| Lennox-Gastaut syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.