Pregabalin
Pregabalin
Definition
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
Also known as 3-(Aminomethyl)-5-methyl-hexanoic Acid, 3-Isobutyl GABA, CI 1008, Lyrica, PD 144723, PREGABALIN — per NCIT
Also identified as
- ATC N02BF per NCIT
- NCIT NCIT:C64625 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Fibromyalgia | may treat | MEDRT · Public domain (U.S. Government work) |
| Spinal cord injury | may treat | MEDRT · Public domain (U.S. Government work) |
| Visual epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.