Memantine

Definition

A low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist.

NCIT:C73269 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as MEMANTINE — per NCIT

Also identified as

ATC N06DA per NCIT
ATC N06DX per NCIT
NCIT NCIT:C73269 per NCIT

Indications

Disease	Relation	Source
Alzheimer's disease	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Central nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0
Nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.