Ibuprofen

Definition

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)

NCIT:C561 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as (.+ -.)-p-Isobutylhydratropic acid, Advil, Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-, IBUPROFEN, Motrin, p-Isobutylhydratropic Acid — per NCIT

Also identified as

ATC C01EB per NCIT
ATC G02CC per NCIT
ATC M01AE per NCIT
ATC M02AA per NCIT
ATC N02AJ per NCIT
ATC R02AX per NCIT
NCIT NCIT:C561 per NCIT

Indications

Disease	Relation	Source
Ankylosing spondylitis	may treat	MEDRT · Public domain (U.S. Government work)
Bursitis	may treat	MEDRT · Public domain (U.S. Government work)
Gout	may treat	MEDRT · Public domain (U.S. Government work)
Juvenile idiopathic arthritis	may treat	MEDRT · Public domain (U.S. Government work)
Osteoarthritis	may treat	MEDRT · Public domain (U.S. Government work)
Premenstrual tension	may treat	MEDRT · Public domain (U.S. Government work)
Rheumatoid arthritis	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Bone element	may treat a disease of this organ	DERIVED · CC BY 4.0
Musculoskeletal system	may treat a disease of this organ	DERIVED · CC BY 4.0
Skeletal joint	may treat a disease of this organ	DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.