Mesna
Mesna
Definition
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)
Also known as 2-Mercaptoethanesulfonate, Sodium Salt, 2-Mercaptoethanesulfonic Acid Sodium Salt, Ausobronc, D-7093, Filesna, Mercaptoethane Sulfonate, Mercaptoethanesulfonate, MESNA, Mesnex, Mesnil, Mesnum, Mexan, Mistabron, Mistabronco, Mitexan, Mucofluid, Mucolene, Sodium 2-Mercaptoethane Sulfonate, Sodium 2-Mercaptoethanesulphonate, UCB 3983, Uromitexan, Ziken — per NCIT
Also identified as
- ATC R05CB05 per RXNORM
- ATC V03AF01 per RXNORM
- NCIT NCIT:C192 per NCIT
- SCTID 108821000 per RXNORM
- SCTID 386922000 per RXNORM
- UNII NR7O1405Q9 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cystitis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Cystitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Urinary bladder | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.