Warfarin
Warfarin
Definition
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.
Also known as 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone, 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin, 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin, 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin, 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin, 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, Co-Rax, Compound 42, Rodex, WARF Compound 42, WARFARIN — per NCIT
Also identified as
- ATC B01AA per NCIT
- NCIT NCIT:C945 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Atrial fibrillation | may prevent | MEDRT · Public domain (U.S. Government work) |
| Coronary thrombosis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Myocardial infarction | may prevent | MEDRT · Public domain (U.S. Government work) |
| Pulmonary embolism | may prevent | MEDRT · Public domain (U.S. Government work) |
| Stroke | may prevent | MEDRT · Public domain (U.S. Government work) |
| Transient ischemic attack | may prevent | MEDRT · Public domain (U.S. Government work) |
| Atrial fibrillation | may treat | MEDRT · Public domain (U.S. Government work) |
| Pulmonary embolism | may treat | MEDRT · Public domain (U.S. Government work) |
| Stroke | may treat | MEDRT · Public domain (U.S. Government work) |
| Thrombophlebitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Vein | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.