Amikacin

Amikacin

Definition

A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.

Also known as AMIKACIN — per NCIT

Also identified as

Indications

Disease Relation Source
Acinetobacter infectious disease may treat MEDRT · Public domain (U.S. Government work)
Central nervous system infectious disorder may treat MEDRT · Public domain (U.S. Government work)
Endocarditis may treat MEDRT · Public domain (U.S. Government work)
Escherichia coli infection may treat MEDRT · Public domain (U.S. Government work)
Klebsiella infectious disease may treat MEDRT · Public domain (U.S. Government work)
Mycobacterial infectious disease may treat MEDRT · Public domain (U.S. Government work)
Proteus infectious disease may treat MEDRT · Public domain (U.S. Government work)
Pseudomonas infection may treat MEDRT · Public domain (U.S. Government work)
Respiratory tract infectious disorder may treat MEDRT · Public domain (U.S. Government work)
Skin disorder caused by infection may treat MEDRT · Public domain (U.S. Government work)
Staphylococcal infection may treat MEDRT · Public domain (U.S. Government work)
Urinary tract infection may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Cardiovascular system may treat a disease of this organ DERIVED · CC BY 4.0
Central nervous system may treat a disease of this organ DERIVED · CC BY 4.0
Endocardium may treat a disease of this organ DERIVED · CC BY 4.0
Heart may treat a disease of this organ DERIVED · CC BY 4.0
Nervous system may treat a disease of this organ DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.